Infertility, assisted reproduction technologies and imprinting disturbances: a Dutch study
نویسندگان
چکیده
منابع مشابه
Genomic imprinting and assisted reproduction
Imprinted genes exhibit a parent-of-origin specific pattern of expression. Such genes have been shown to be targets of molecular defects in particular genetic syndromes such as Beckwith-Wiedemann and Angelman syndromes. Recent reports have raised concern about the possibility that assisted reproduction techniques, such as in vitro fertilization or intracytoplasmic sperm injection, might cause g...
متن کاملA review of known imprinting syndromes and their association with assisted reproduction technologies.
An association between assisted reproduction technologies (ART) and abnormal genomic imprinting in humans has been recognized for several years; however, the magnitude of this risk and the spectrum of imprinting syndromes to which the risk applies remains unknown. Nine human imprinting syndromes have been identified but current evidence links ART with only three: Beckwith-Wiedemann syndrome, An...
متن کاملUterine Imaging in Infertility and Assisted Reproduction
Uterine pathologies are found to be present in 25% of infertile patients [2] . Structural abnormalities of the uterus, such as leiomyoma, endom etrial polyps, intrauterine adhesions (IUAs), adenomyosis and mullerian anomalies, may affect the reproductive outcome adversely, by interfering with implantation or causing spontaneous abortion. Therefore, exclusion of any uterine pathology becomes an ...
متن کاملImprinting disorders after assisted reproductive technologies.
PURPOSE OF REVIEW To assess the evidence of an increased risk of imprinting diseases in children born after use of assisted reproductive technologies. RECENT FINDINGS Imprinting disorders occur when the epigenetic programming during gametogenesis is disturbed, or when this programming is not sufficiently sustained during the process of fertilization and early embryonic development. Ten case o...
متن کاملCharacterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies.
BACKGROUND There is an increased incidence of rare imprinting disorders associated with assisted reproduction technologies (ARTs). The identification of epigenetic changes at imprinted loci in ART infants has led to the suggestion that the techniques themselves may predispose embryos to acquire imprinting errors and diseases. However, it is still unknown at what point(s) these imprinting errors...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2007
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/dem172